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L Austin Doyle Selected Research

MK 2206

11/2020A Phase I Study of Dinaciclib in Combination With MK-2206 in Patients With Advanced Pancreatic Cancer.
5/2020Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035).
1/2019Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation.
4/2017Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial.
6/2015Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer.
7/2014A phase I trial of MK-2206 in children with refractory malignancies: a Children's Oncology Group study.
4/2014Preclinical and early clinical evaluation of the oral AKT inhibitor, MK-2206, for the treatment of acute myelogenous leukemia.

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L Austin Doyle Research Topics

Disease

20Neoplasms (Cancer)
01/2022 - 04/2002
8Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2018 - 08/2003
6Leukemia
07/2017 - 08/2003
5Breast Neoplasms (Breast Cancer)
01/2021 - 08/2003
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2010 - 02/2003
4Disease Progression
01/2021 - 10/2012
4Exanthema (Rash)
01/2020 - 01/2014
3Lung Neoplasms (Lung Cancer)
01/2010 - 07/2005
2Brain Neoplasms (Brain Tumor)
08/2022 - 07/2008
2Adenocarcinoma
01/2021 - 04/2017
2Pancreatic Neoplasms (Pancreatic Cancer)
11/2020 - 04/2017
2Ovarian Neoplasms (Ovarian Cancer)
05/2020 - 01/2020
2Carcinoma (Carcinomatosis)
05/2020 - 10/2012
2Nausea
01/2020 - 01/2014
2Vomiting
01/2020 - 01/2014
2Diarrhea
01/2020 - 01/2014
2Fatigue
04/2015 - 01/2014
2Sarcoma (Soft Tissue Sarcoma)
03/2015 - 04/2013
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
11/2014 - 11/2010
2Lymphoma (Lymphomas)
11/2014 - 11/2010
2Pathologic Complete Response
11/2012 - 06/2005
1Glioma (Gliomas)
08/2022
1Ovarian Epithelial Carcinoma
05/2020
1Sepsis (Septicemia)
01/2020
1Plexiform Neurofibroma
01/2020
1Neurofibromatosis 1 (Neurofibromatosis Type I)
01/2020
1Pneumonia (Pneumonitis)
01/2020
1Paronychia
01/2020
1Neoplasm Metastasis (Metastasis)
04/2017
1Colorectal Neoplasms (Colorectal Cancer)
06/2015
1Hypercholesterolemia
04/2015
1Thrombocytopenia (Thrombopenia)
04/2015
1Mucositis
03/2015
1Rhabdomyosarcoma
03/2015
1Ewing Sarcoma (Sarcoma, Ewing)
03/2015
1Osteosarcoma (Osteogenic Sarcoma)
03/2015
1Waldenstrom Macroglobulinemia (Macroglobulinemia)
11/2014
1Multiple Myeloma
11/2014
1Ascites
10/2012
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
03/2011
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
11/2010
1Non-Hodgkin Lymphoma (Lymphosarcoma)
11/2010
1Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
11/2010
1Melanoma (Melanoma, Malignant)
01/2010
1HIV Infections (HIV Infection)
07/2008
1Esophageal Neoplasms (Esophageal Cancer)
02/2008

Drug/Important Bio-Agent (IBA)

9alvocidib (flavopiridol)IBA
01/2018 - 08/2003
7AZD 6244IBA
08/2022 - 06/2011
7MK 2206IBA
11/2020 - 04/2014
7Cytarabine (Cytosar-U)FDA LinkGeneric
01/2018 - 07/2010
6Mitoxantrone (Novantrone)FDA LinkGeneric
01/2018 - 07/2010
5Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2022 - 06/2011
5Proteins (Proteins, Gene)FDA Link
04/2017 - 08/2003
4PlatinumIBA
05/2020 - 02/2003
4GemcitabineFDA Link
01/2020 - 08/2005
4temsirolimusFDA Link
04/2015 - 11/2010
4Pharmaceutical PreparationsIBA
04/2014 - 02/2003
3Messenger RNA (mRNA)IBA
01/2020 - 08/2003
3Biomarkers (Surrogate Marker)IBA
06/2015 - 10/2012
3cixutumumabIBA
04/2015 - 04/2013
3Carboplatin (JM8)FDA LinkGeneric
07/2008 - 08/2005
2Daunorubicin (Cerubidine)FDA LinkGeneric
01/2018 - 09/2015
2Biological ProductsIBA
04/2015 - 07/2014
2TOR Serine-Threonine KinasesIBA
03/2015 - 11/2010
2Paclitaxel (Taxol)FDA LinkGeneric
07/2008 - 02/2008
2ATP-Binding Cassette Transporters (ABC Transporters)IBA
08/2004 - 10/2003
2Adenosine Triphosphate (ATP)IBA
08/2004 - 10/2003
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
10/2003 - 08/2003
1cediranib (AZD2171)IBA
01/2022
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2022
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2022
1Hormones (Hormone)IBA
01/2021
1capivasertibIBA
01/2021
1Cyclin-Dependent Kinases (cdk Proteins)IBA
11/2020
1dinaciclibIBA
11/2020
1Creatine Kinase (Creatine Phosphokinase)IBA
01/2020
1berzosertibIBA
01/2020
1MK-8776IBA
10/2017
1Fluorouracil (Carac)FDA LinkGeneric
04/2017
1Oxaliplatin (Eloxatin)FDA LinkGeneric
04/2017
1Alanine Transaminase (SGPT)IBA
04/2015
1ElectrolytesIBA
03/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
03/2015
1Insulin (Novolin)FDA Link
03/2015
1Bortezomib (Velcade)FDA Link
11/2014
1Alkaline PhosphataseIBA
07/2014
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
01/2014
1N-(2-naphthalene)sulfonyl-DL-tryptophan (A 91)IBA
11/2012
1Cisplatin (Platino)FDA LinkGeneric
10/2012
1Phosphotransferases (Kinase)IBA
06/2011
1ixabepilone (BMS 247550)FDA Link
01/2010
1Epothilones (Epothilone)IBA
01/2010
1epothilone B (EPO906)IBA
01/2010
1Excipients (Suspending Agents)IBA
01/2010

Therapy/Procedure

11Therapeutics
01/2021 - 07/2005
11Drug Therapy (Chemotherapy)
04/2017 - 02/2003
1FLAM regimen
07/2017
1Homologous Transplantation
11/2012
1Pneumonectomy (Lung Volume Reduction)
01/2010
1Organ Transplantation
07/2008